세포라니드

한글명:세포라니드

카스 번호60925-61-3

상품명:Ceforanide

CBNumberCB2501637

분자식C20H21N7O6S2

포뮬러 무게519.55

MOL 파일60925-61-3.mol

동의어(한글)

세포라니드

화학적 성질

녹는점	>150° (dec)
밀도	1.79±0.1 g/cm3(Predicted)
저장 조건	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도	알칼리성 용액(약간), DMSO(약간, 가온), 메탄올(약간)에 용해됨
산도 계수 (pKa)	2.52±0.10(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 옅은 갈색까지
안정성	흡습성
InChIKey	SLAYUXIURFNXPG-CRAIPNDOSA-N

위험 및 안전 성명

HS 번호

2941906000

그림문자(GHS)

세포라니드 화학적 특성, 용도, 생산

개요
Ceforanide is a second generation cephalosporin with good β-lactamase resistance. It has a serum half-life of about three hours, allowing twice-daily dosing.
용도
Ceforanide is a cephalosporin based antibiotic used in the sterilization in various medical procedures.
정의
ChEBI: A second-generation cephalosporin antibiotic with {[1-(carboxymethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and 2-(aminomethyl)phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is effective against many col forms, including Escherichia coli, Klebsiella, Enterobacter and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Ari ona species.
Antimicrobial activity
A semisynthetic parenteral cephalosporin with activity broadly similar to that of cefalotin. Its activity in vitro is significantly reduced in the presence of serum. A 1 g intravenous dose achieves a concentration of c. 135 mg/L at the end of infusion. The response after 0.25, 0.5 and 1 g intravenous doses is essentially linear. A 1 g intramuscular dose produces mean peak values of around 70 mg/L. Plasma protein binding is around 85%.
It is almost entirely eliminated in the urine with a halflife of about 2.5 h, 80–95% being recovered in the first 12 h. The half-life is inversely related to renal function, rising to around 20 h when the creatinine clearance falls below 5 mL/min. About half the dose is removed by hemodialysis over 6 h.
It is generally well tolerated; phlebitis and pain at the site of injection are reported in some patients with occasional transient neutropenia and increased transaminase levels. It has been used principally for the treatment of infections due to Gram-positive cocci, including staphylococcal and streptococcal soft-tissue infections, but is no longer widely available.

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