P1

P1 화학적 특성, 용도, 생산

• 용도

  P1 is a starting material and useful building block of various pharmaceuticals.

• 효소 저해제

  This cell-permeable PDI inhibitor (FW = 583.70 g/mol; CAS 1461648-55- 4; Soluble to 100 mM in DMSO; N-[(1,1-dimethylethoxy)carbonyl]-Lphenylalanyl-O-(ethenyl-sulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide) targets protein disulfide isomerase (IC50 = 1.7 μM), an enzyme that assists in the folding of cellular proteins within the endoplasmic reticulum of mammalian cells. P1 reduces the proliferation of numerous cancer cell lines, with nominal GI50 values of ～4 μM. PDI binds to the axonal microtubuleassociated protein known as Tau, mainly through its thioredoxin-like catalytic domain, by forming a one-to-one complex that prevents Tau misfolding.

P1 공급 업체

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