InSolution IKK-2 Inhibitor IV - Calbiochem

InSolution IKK-2 Inhibitor IV - Calbiochem 화학적 특성, 용도, 생산

• 일반 설명

  IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC₅₀ = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC₅₀ in the range of 0.15-2.5 μM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC₅₀ = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).

• Biochem/physiol Actions

  Cell permeable: yes

InSolution IKK-2 Inhibitor IV - Calbiochem 공급 업체

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