Proglumide

한글명:Proglumide

카스 번호6620-60-6

상품명:Proglumide

CBNumberCB2479493

분자식C18H26N2O4

포뮬러 무게334.41

MOL 파일6620-60-6.mol

화학적 성질

녹는점	148-150°C
끓는 점	471.21°C (rough estimate)
밀도	1.1944 (rough estimate)
굴절률	1.5700 (estimate)
저장 조건	Keep in dark place,Sealed in dry,Room Temperature
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	4.51±0.10(Predicted)
색상	크리스탈
CAS 데이터베이스	6620-60-6(CAS DataBase Reference)
EPA	Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)

위험 및 안전 성명

독성	LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)

그림문자(GHS)

Proglumide 화학적 특성, 용도, 생산

개요
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
화학적 성질
White Solid
용도
Anticholinergic.
부작용
An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.
Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.
Safety Profile
Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.
효소 저해제
This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.

Proglumide 준비 용품 및 원자재

Proglumide 공급 업체

Proglumide 관련 검색

Send Inquriy