Clindamycin hydrochloride

한글명:Clindamycin hydrochloride

카스 번호21462-39-5

상품명:Clindamycin hydrochloride

CBNumberCB2398837

분자식C18H34Cl2N2O5S

포뮬러 무게461.44

MOL 파일21462-39-5.mol

화학적 성질

녹는점	141°C
저장 조건	2-8°C
용해도	H₂O: 50 mg/mL, 투명, 무색
물리적 상태	Solid
색상	흰색에서 황백색까지
수용성	H2O: 50mg/mL
BRN	4070786
안정성	흡습성
InChIKey	AUODDLQVRAJAJM-XJQDNNTCSA-N
SMILES	[C@@H]1([C@@H]([C@H](C)Cl)NC(=O)[C@@H]2C[C@@H](CCC)CN2C)[C@H](O)[C@H](O)[C@H]([C@@H](SC)O1)O.Cl \|&1:0,1,2,8,10,17,19,21,22,r\|
CAS 데이터베이스	21462-39-5(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36-37/39
WGK 독일	2
RTECS 번호	GF2275000
F 고인화성물질	10
HS 번호	29419000

그림문자(GHS)

Clindamycin hydrochloride 화학적 특성, 용도, 생산

화학적 성질
White Solid
용도
Clindamycin hydrochloride is a salt of clindamycin, a semi-synthetic lincosamide. The hydrochloride salt forms at the basic N-ethylproline moiety and is the preferred pharmaceutical formulation. Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin hydrochloride acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Clindamycin hydrochloride has been extensively studied with over 8,000 literature citations.
일반 설명
Chemical structure: macrolide
색상 색인 번호
This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.
Clinical Use
Clindamycin is recommended for the treatment of a widevariety of upper respiratory, skin, and tissue infections causedby susceptible bacteria. Its activity against streptococci,staphylococci, and pneumococci is indisputably high, and it isone of the most potent agents available against somenon–spore-forming anaerobic bacteria, the Bacteroides spp.in particular. An increasing number of reports of clindamycin-associated GI toxicity, which range in severity fromdiarrhea to an occasionally serious pseudomembranous colitis,have, however, caused some clinical experts to call for areappraisal of the role of this antibiotic in therapy.Clindamycin- (or lincomycin)-associated colitis may be particularlydangerous in elderly or debilitated patients and hascaused deaths in such individuals. The colitis, which is usuallyreversible when the drug is discontinued, is now believedto result from an overgrowth of a clindamycin-resistant strainof the anaerobic intestinal bacterium Clostridium difficile.229The intestinal lining is damaged by a glycoprotein endotoxinreleased by lysis of this organism.
The glycopeptide antibiotic vancomycin has been effectivein the treatment of clindamycin-induced pseudomembranouscolitis and in the control of the experimentally induced bacterial condition in animals. Clindamycin shouldbe reserved for staphylococcal tissue infections, such as cellulitisand osteomyelitis, in penicillin-allergic patients andfor severe anaerobic infections outside the central nervoussystem. Ordinarily, it should not be used to treat upper respiratorytract infections caused by bacteria sensitive to othersafer antibiotics or in prophylaxis.

Clindamycin hydrochloride 준비 용품 및 원자재

Clindamycin hydrochloride 공급 업체

Clindamycin hydrochloride 관련 검색

Send Inquriy