메틸트랜스-3-(Boc-aMino…

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

메틸트랜스-3-(Boc-aMino… 화학적 특성, 용도, 생산

• Synthesis

  Methyl /rara-3-amino-cyclobutanecarboxylate hydrochloride (39.94 g, 241 mmol) was suspended in dichloromethane (400 ml). The solution was cooled to 0°C before Et3N (4 equiv., 134 ml, 965 mmol) and Boc anhydride (1.2 equiv., 63.2 g, 289 mmol) were added. The cooling bath was removed and the mixture was stirred while slowly allowing to warm up to room temperature. After 20 hours of stirring, the salts were filtered off and the filtrate was rinsed three times with water. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The residue was triturated in heptane, the solid was filtered off and dried in air flow to give Methyl trans-3-(boc-amino)cyclobutanecarboxylate as a white solid.
  

메틸트랜스-3-(Boc-aMino… 공급 업체

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