MK8245

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H242：가열하면 화재를 일으킬 수 있음

• 예방조치문구

  P210：열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.

  P234：원래의 용기에만 보관하시오.

  P235：저온으로 유지하시오.

  P240：용기와 수용설비를 접지 및 접합시키시오.

  P370+P378：화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.

  P403：환기가 잘 되는 곳에 보관하시오.

MK8245 화학적 특성, 용도, 생산

• 개요

  MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC₅₀s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ⁵- and Δ⁶-desaturases (IC₅₀s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC₅₀ = 39.8 nM).

• 용도

  This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

MK8245 준비 용품 및 원자재

MK8245 공급 업체

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