MF-63

MF-63 화학적 특성, 용도, 생산

• 개요

  Microsomal prostaglandin E₂ synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE₂. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC₅₀ = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC₅₀ = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE₂ synthesis in the stomach.

• 용도

  MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

MF-63 공급 업체

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