(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one

(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one 화학적 특성, 용도, 생산

• 개요

  This alkaloid, in which the pregnane keto group of the preceding base is reduced to a secondary hydroxyl group, occurs in small amounts in Pachysandra termi_x0002_nalis Sieb. et Zucco It is laevorotatory having [O:]D - 18° (CHC13). Oxidation with chromic acid yields Pachystermine A.

• 참고 문헌

  Kikuchi, Uyeo., Tetrahedron Lett., 3473 (1965)
  Kikuchi, Uyeo., Chern. Pharrn. Bull., 15, 549 (1967)
  Partial synthesis:
  Kikuchi et aZ., Tetrahedron Lett., 909 (1968)