9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID 화학적 특성, 용도, 생산

• 개요

  Prostaglandin D₂ (PGD₂) is one of the five primary enzymatic prostaglandins derived directly from PGH₂. PGD₂ is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD₂ is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ¹²-PGD₂ is one of the initial chemical decomposition products of PGD₂. Δ¹²-PGD₂ is an intermediate in the pathway leading to Δ¹²-PGJ₂, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of Δ¹²-PGD₂ involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.

9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID 공급 업체

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