Gonadorelin acetate

한글명:Gonadorelin acetate

카스 번호34973-08-5

상품명:Gonadorelin acetate

CBNumberCB22130587

분자식C57H79N17O15

포뮬러 무게1242.36

MOL 파일34973-08-5.mol

화학적 성질

녹는점	>155oC (dec.)
저장 조건	Hygroscopic, Refrigerator, Under inert atmosphere
용해도	메탄올(약간 용해됨), 물(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
안정성	흡습성
InChIKey	NGCGMRBZPXEPOZ-NWVXUHCVNA-N
CAS 데이터베이스	34973-08-5

그림문자(GHS)

Gonadorelin acetate 화학적 특성, 용도, 생산

개요
Gonadorelin Acetate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.
Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
용도
Gonadorelin Acetate is used in various agricultural and biological studies. It was used to study ovulation synchronization in dairy cows.
Synthetic GnRH (gonadorelin hydrochloride [Factrel]) is marketed for diagnostic purposes to differentiate between pituitary and hypothalamic defects in patients with delayed puberty and hypogonadotropic hypogonadism. After a baseline serum LH is drawn, a single 100-mcg GnRH dose is administered subcutaneously or intravenously. An increase in serum LH of greater than 10 mIU/ml is considered a positive response. Synthetic GnRH (gonadorelin acetate [Lutrepulse]) is marketed for the treatment of infertile women who are anovulatory and have GnRH deficiency. In this protocol, a pump administers GnRH in pulses to promote a physiologic cycle. Because of the complexity of administration, this treatment modality was rarely used, and this product is no longer available in the United States.
주요 응용
Ovarian follicular cysts (veterinary medicine)
Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)
Indications
Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.
Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.
생물학적 활성
Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle- stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.
부작용
Gonadorelin side effects: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or. skin rash.
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.

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