2-(N-2”-FLURO-4”-IODOPHENYL)AMINO-3,4-DIFLOURO벤조산

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H332：흡입하면 유해함

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

2-(N-2”-FLURO-4”-IODOPHENYL)AMINO-3,4-DIFLOURO벤조산 화학적 특성, 용도, 생산

• 화학적 성질

  Off-White Solid

• 용도

  Intermediate in the preparation of MEK inhibitors.

• Synthesis

  To a solution of methyl-3,4-diflluoro-2-((2-flluoro-4-iodophenyl)amino)benzoate (23, 6.0 g, 23.8 mmol) in methanol (80 mL) and water (80 mL) was added LiOH (7.8 g, 195 mmol). The reaction mixture was stirred at 78 C in an oil bath for 1 h. After cooling, the reaction mixture was acidified to pH = 2 with a 2 N HCl solution. The solid was filtered and washed with water to provide 2-(2-Fluoro-4-iodoanilino)-3,4-difluoro benzoic Acid (5.11 g, 96%) as a white solid.
  

2-(N-2”-FLURO-4”-IODOPHENYL)AMINO-3,4-DIFLOURO벤조산 준비 용품 및 원자재

2-(N-2”-FLURO-4”-IODOPHENYL)AMINO-3,4-DIFLOURO벤조산 공급 업체

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