바도카인

바도카인 화학적 특성, 용도, 생산

• Originator

  Vadocaine hydrochloride ,ZYF Pharm Chemical

• Manufacturing Process

  3-Chloro-4',6'-dimethyl-o-propananisidide was prepared by using 92.8 g (0.615 mol) 4,6-dimethyl-o-anisidine and 86 g (0.68 mol) of 3-chloropropionyl chloride, melting point 123-125°C. A mixture containing 40 g (0.165 mol) of 3-chloro-4',6'-dimethyl-o-propananisidide, 54.3 g of 3-methyl piperidine, and 330 ml of anhydrous benzene was heated for 72 hours at 65°C. 47.7 g (84.5%) of N-(2-methoxy-4,6-dimethylphenyl)-2-methyl-1- piperidinepropanamide hydrochloride was obtained by deposition of product in anhydrous acetone saturated with hydrogen chloride; melting point 192-193°C (crystallization from a mixture isopropanol-acetone).

• Therapeutic Function

  Antitussive, Local anesthetic

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