Nalmefene

한글명:Nalmefene

카스 번호55096-26-9

상품명:Nalmefene

CBNumberCB1747788

분자식C21H25NO3

포뮬러 무게339.44

MOL 파일55096-26-9.mol

화학적 성질

녹는점	182-185?C
끓는 점	507.9±50.0 °C(Predicted)
밀도	1.38±0.1 g/cm3(Predicted)
저장 조건	2-8°C
용해도	클로로포름(약간 용해됨), 디클로로메탄(약간 용해됨), DMSO(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	pKa 7.63(H2O) (Uncertain)
색상	흰색에서 황백색까지
CAS 데이터베이스	55096-26-9
NIST	Nalmefene(55096-26-9)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
유해 물질 데이터	55096-26-9(Hazardous Substances Data)

그림문자(GHS)

Nalmefene MSDS

Nalmefene 화학적 특성, 용도, 생산

화학적 성질
Off-White Solid
용도
A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist.
Biological Functions
Nalmefene (Revex) is a long-acting injectable pure opioid antagonist recently introduced in the United States. It binds all opioid receptors and reverses the effects of opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism is slow and occurs via glucuronide conjugation to inactive metabolites. Its half-life of 11 hours is about 5 times that of naloxone. Indications include use in postoperative settings to reverse respiratory depression and in opioid overdose. Due to the long duration of action of nalmefene, however, naloxone may be preferred for treatment of overdose because it produces a shorter duration of withdrawal effects.
일반 설명
Nalmefene (Revex) is a pure opioid antagonist that is the6-methylene analog of naltrexone. It is available as a solutionfor IV, IM, or subcutaneous (SC) administration toreverse the effects of opioids after general anesthesia andin the treatment of overdose. It is longer acting than naloxonebut otherwise has a similar pharmacodynamic andmetabolic (3-glucuronidation) profile. Nalmefene hashigher oral bioavailability (approximately 40%) thannaloxone or naltrexone and is currently being investigatedas an oral treatment for pathological gambling and alcoholabuse.

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