파니페em

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P321：(…) 처치를 하시오.

  P330：입을 씻어내시오.

  P332+P313：피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

  P362：오염된 의복을 벗고 세척 후에 재사용하기

  P501：...에 내용물 / 용기를 폐기 하시오.

파니페em 화학적 특성, 용도, 생산

• 용도

  Panipenem is a broad spectrum carbapenem antibacterial and antimicrobial agent working against Gram-negative and Gram-positive organisms.

• Antimicrobial activity

  A 3-acetimidoylpyrrolidinyl-substituted carbapenem with no methyl group at the C-1 position. It has broad-spectrum antibacterial activity against Gram-positive and Gramnegative organisms very similar to that of other carbapenems. Activity against Ps. aeruginosa is similar to that of imipenem. It is co-administered in a ratio of 1:1 with betamipron (N-benzoyl-β-alanine), a renal anion transport inhibitor that decreases nephrotoxicity. Panipenem is slightly more stable to hydrolysis by dehydropeptidase than imipenem, but not as stable as meropenem or biapenem. It is hydrolyzed by carbapenemases.
  Mean maximum blood concentrations following intravenous infusion of 0.5 g and 0.75 g of each component were 37 and 61 mg/L for panipenem and 24 and 39 mg/L for betamipron. Following intravenous infusion in children (10 mg or 20 mg of each component per kg), the half-life of panipenem was about 1.2 h; that of betamipron about 0.9 h. Drug levels in the CSF were at least eight-fold lower than serum concentrations.
  Side effects are similar to those reported for other carbapenems (incidence <10%) and are generally mild. Patients with a history of previous hypersensitivity reactions to penicillins, cephalosporins or other β-lactam antibiotics should be treated cautiously.
  Clinical use in serious infections is similar to that of other carbapenems.

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