가도베르세타미드(200MG)

가도베르세타미드(200MG) 화학적 특성, 용도, 생산

• 개요

  The contrast agent gadoversetamide was launched in the US as a solution for i.v. injection to be used prior to magnetic resonance imaging (MRI) in patients with anomalous blood-brain barrier or anomalous vascularity in the central nervous system or in the liver. This chelate obtained by complexation of paramagnetic gadolinium(III) ion and DTPA-bis- (methoxyethylamide) ligand enhances visualization of lesions including tumors in the brain, spine and liver due to the effect of Gd(III)-water interaction on the proton magnetic relaxation of water. The small molecular size gadoversetamide belongs to the class of extracellular contrast agents. A phase III, multicenter, double-blind, parallel group trial showed that gadoversetamide was well tolerated and as efficient as gadopentetate dimeglumine (Schering) in hepatic magnetic resonance imaging of patients with suspected liver pathology.

• 용도

  Diagnostic aid (paramagnetic, brain disorders; spine disorders.

• 정의

  ChEBI: A gadolinium coordination entity that consists of Gd3+ coordinated to 3,6,9-triazaundecadiamide in which each of the amide nitrogens is substituted by a 2-methoxyethyl group and in which the nitrogens at positions 3, 6, and 9 are each ubstituted by carboxylatomethyl group. The gadolinium is coordinated to the three tertiary amino groups as well as to the carboxylate groups. A white odourless powder that is freely soluble in water, gadoversetamide has paramagnetic properties and is used s a contrast agent in magnetic resonance imaging. It distributes mainly in extracellular fluid, but does not cross the blood-brain barrier. It is used particularly in imaging the brain, spine and liver.

가도베르세타미드(200MG) 준비 용품 및 원자재

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