CAMP-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT

CAMP-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT 화학적 특성, 용도, 생산

• 용도

  Protein Kinase A (PKA) Catalytic Subunit from bovine heart has been used-
  
  • to study PKA-mediated inhibition of IRK1 (inwardly rectifying K⁺) channels
  • in in Vitro PKA pPhosphorylation assay
  • in Vitro affinity binding assays
  • to study effects of PKA on inspiratory drive currents in functionally active motorneurons

• 일반 설명

  Protein Kinase A enzyme is composed of two subunits- catalytic and regulatory. The catalytic subunit exists as a monomer in the presence of cAMP and has a molecular weight of 40,862 Da.

• Biochem/physiol Actions

  Protein Kinase A (PKA) controls the transduction of?Hedgehog?signaling and participates in proliferation and fate specification. It phosphorylates several neurotransmitter receptors, transcription factors and constituents of various intracellular signaling pathways.

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