IgM, λ from murine myeloma was used as standard in ELISA and as isotype control in immunohistochemistry applications.
일반 설명
IgM antibodies are present as pentamers in the serum and are produced in response to antigens IgM, λ from murine myeloma is produced by MOPC 104E tumor line introduced subcutaneously in BALB/c mice. It specifically recognizes mouse IgM, λ. Identity and purity of the immunoglobulin is established by immunoelectrophoresis.
Biochem/physiol Actions
IgM antibodies are produced initially during B-cell development. IgM participates in opsonization and compliment fixation. Defect in IgM production is observed in X-linked agammaglobulinemia.
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