Fmoc-Lys(Pal-Glu-OtBu)-OH

한글명:Fmoc-Lys(Pal-Glu-OtBu)-OH

카스 번호1491158-62-3

상품명:Fmoc-Lys(Pal-Glu-OtBu)-OH

CBNumberCB13054762

분자식C46H69N3O8

포뮬러 무게792.06

MOL 파일1491158-62-3.mol

화학적 성질

끓는 점	944.2±65.0 °C(Predicted)
밀도	1.099±0.06 g/cm3(Predicted)
산도 계수 (pKa)	3.88±0.21(Predicted)
물리적 상태	Solid
색상	White to off-white
InChIKey	SUFBOZUGILQOQW-FMQAFZDONA-N
SMILES	C(O)(=O)[C@@H](N(C1C2=C(C=CC=C2)C2=C1C=CC=C2)C(OC)=O)CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(OC(C)(C)C)=O \|&1:3,31,r\|

Fmoc-Lys(Pal-Glu-OtBu)-OH 화학적 특성, 용도, 생산

용도
Fmoc-Lys(Pal-Glu-OtBu)-OH can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
용도
Fmoc-Lys (Pal-Glu-OtBu)-OH is a non-cleavable antibody-drug conjugates linker capable of synthesizing antibody-drug conjugates. It can also be used as an alkyl chain-based PROTAC linker for the synthesis of PROTACs.
주요 응용
Fmoc-Lys(Pal-Glu-OtBu)-OH is a racemic, solid-phase, industrial building block for the synthesis of peptides and polypeptides. This product is used in the synthesis of liraglutide (a peptide), which is used to treat type 2 diabetes mellitus. It is synthesized by a solid phase process using coupling reactions with an acid labile linker. This product has been shown to be an efficient building block for the synthesis of peptides and polypeptides that have a sequence that can be varied by changing the protecting group on the amino acid.
Synthesis

In a flask aqueous sodium carbonate (1.8 g) was prepared followed by addition of THF (800 mL) and then this mixture was cooled to 0-10 0C. To this mixture, (S)-2-((((9Hfluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid (4.59 g) was added. Then, a solution of 1 -(tert-butyl) 5-(2,5-dioxopyrrolidin-1-yl) palmitoyl-L-glutamate (corresponding to 5 g of 5-(tert-butoxy)-5-oxo-4-palmitamidopentanoic acid) prepared according to example 2, was slowly added to above mixture at about 5 0C. The reaction mixture was stirred for about 2 hours at 25 0C followed by addition of water (600 mL). The solvents were subjected to distillation and then the pH of the obtained compound is adjusted to 3.0 using 5N hydrochloric acid. The mixture was stirred for 1-2 hours and resulting solid was isolated filtration, washing with water (30 mL). The obtained solid was dried under vacuum for 8 hours at about 45°C to afford title compound in -85% yield.

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