3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile 화학적 특성, 용도, 생산

• 개요

  NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC₅₀ = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.

• 용도

  NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile 공급 업체

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