RNA polymerase II subunit E (POLR2E) is also known as RPB5. It is a subunit of eukaryotic RNA polymerase II. This subunit is also shared by RNA polymerases I and III. The gene encoding POLR2E is localized on human chromosome 19p13.3.
Biochem/physiol Actions
RNA polymerase II subunit E (POLR2E) is a target for transcriptional modulation in signal transduction. It binds to transcription partners of RNA polymerase II and modulates transcription and gene expression. POLR2E also associates with hepatitis B virus X protein (HBx), which is known to have a role in the progression of hepatocellular carcinoma.
