RO-31-7549

RO-31-7549 화학적 특성, 용도, 생산

• 용도

  It is a potent inhibitor of protein kinase C (PKC) activity.

• 일반 설명

  A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ₁. Exhibits some degree of PKC isozyme specificity (IC₅₀ = 53 nM for PKC_α, 195 nM for PKC_βI, 163 nM for PKC_βII, 213 nM for PKC_γ, and 175 nM for PKC_ε). Inhibits carbachol-evoked noradrenaline release (IC₅₀ = 600 nM).

• Biochem/physiol Actions

  Cell permeable: yes

RO-31-7549 공급 업체

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