[S-(R*,R*)]-2-아미노-3-메틸-N-[2-(4-모르폴리닐)에틸]펜탄아미드이염산염

[S-(R*,R*)]-2-아미노-3-메틸-N-[2-(4-모르폴리닐)에틸]펜탄아미드이염산염 화학적 특성, 용도, 생산

• 개요

  LM11A-31 is a p75 neurotrophin receptor (p75^NTR) ligand that inhibits nerve growth factor (NGF) binding to p75^NTR-Fc (A₂ = 1,192 nM). It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75^NTR- and concentration-dependent manner. LMA11A-31 also inhibits proNGF-induced cell death of mature oligodendrocytes. In vivo, LMA11A-31 (10-100 mg/kg) improves motor function and coordination in the weight-bearing open-field test and nonweight-bearing swim test and increases survival of oligodendrocytes in a mouse model of spinal contusion injury. It prevents and/or reverses atrophy of forebrain cholinergic neurites and cortical dystrophic neurites in Thy-1 hAPP^Lond/Swe and Tg2576 mice with mid- to late stage Alzheimer''s disease. It also reduces excessive alcohol self-administration in rats and decreases huntingtin (Htt) aggregate formation and striatal cholinergic degeneration in the R6/2 mouse model of Huntington''s disease.

• 용도

  (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide is used for the preparation of peptideamides for treatment of retroviral infection.

[S-(R*,R*)]-2-아미노-3-메틸-N-[2-(4-모르폴리닐)에틸]펜탄아미드이염산염 공급 업체

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