나자나자옥시아나뉴로톡신II

나자나자옥시아나뉴로톡신II 화학적 특성, 용도, 생산

• 개요

  The snake toxin is one of a family of small neurotoxic proteins (MW ～ 8,000 Da) isolated from the venom of elapid snakes (cobras and their relatives). α-Bungarotoxin also binds to certain insect nAChRs (8,9), although a separate α-bungarotoxin–insensitive class of nAChR has been found in some species (9).

• 용도

  The snake toxin, α-bungarotoxin, has been used extensively to characterize vertebrate nAChRs because it selectively binds to certain populations of vertebrate receptors.

• Pharmacology

  The snake toxin binds very tightly to the receptor and competitively blocks the binding of acetylcholine; consequently, radiolabeled α-bungarotoxin has been used to design competitive binding assays to measure the in vitro potencies of competitive ligands such as the neonicotinoids. However, no information concerning the agonist or antagonist nature of test compounds is obtained using these methods. Binding studies using both α-bungarotoxin and imidacloprid have indicated that some insect receptors that do not bind α- bungarotoxin with high affinity do bind imidacloprid (10). Such bungarotoxin-insensitive nicotinic receptors have also been identified using electrophysiology (11).

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