SR 48692

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

• 예방조치문구

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

SR 48692 화학적 특성, 용도, 생산

• 용도

  SR 48692 has been used as a neurotensin?high-affinity receptor 1 (NTSR1) antagonist:
  
  • to explore the function of NTSR1 in glioblastoma (GBM) cells
  • to determine the roles of neurotensin (NT) in the regulation of bile acid?(BA) uptake, in vivo
  • to explore the involvement of NTSR1 versus NTSR2 in mice
  
  

• Biochem/physiol Actions

  SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

SR 48692 공급 업체

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