UROFOLLITROPIN

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H317：알레르기성 피부 반응을 일으킬 수 있음

  H332：흡입하면 유해함

  H334：흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P271：옥외 또는 환기가 잘 되는 곳에서만 취급하시오.

  P272：작업장 밖으로 오염된 의복을 반출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P285：환기가 잘 되지 않는 곳에서는 호흡기 보호구를 착용하시오

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P304+P340：흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

  P304+P341：들이마신 경우,호흡이 어려운 경우 환자를 신선한 공기가 있는 곳으로 옮기고 호흡하기 편한 자세로 안정을 취하게 함

  P312：불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P321：(…) 처치를 하시오.

  P333+P313：피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.

  P342+P311：호흡기 증상이 나타나면 의료기관(의사)의 진찰을 받으시오.

  P363：다시 사용전 오염된 의류는 세척하시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

UROFOLLITROPIN 화학적 특성, 용도, 생산

• 화학적 성질

  Almost white or slightly yellowish powder.

• 용도

  Hormone (follicle-stimulating).

• Clinical Use

  Urofollitropin, a natural product like the menotropins, is obtained from the urine of postmenopausal women and then highly purified so as to contain only FSH, reportedly with only minute amounts of LH. Urofollitropin is used for its ability to stimulate follicle development, such as in women undergoing drug-induced pituitary suppression (GnRH antagonist or superagonist) for purposes of IVF (i.e., multiple follicle development or egg donation). When the number and size of the ovarian follicles are correct, as determined by ultrasound, hCG is administered so as to effect ovulation, and the oocytes are retrieved for IVF.
  This drug also is indicated for women who have infertility caused by polycystic ovary syndrome, which generally is observed clinically as enlarged, cystic ovaries containing relatively small follicles. These patients often develop hirsutism, their androgen and LH levels appear elevated while their FSH levels are low, and the early exposure to these improper hormone levels may be causing the follicular atresia. The patient's monthly cycle is controlled by previous pituitary suppression via treatment with a GnRH superagonist or antagonist; urofollitropin, as an exogenous source of FSH, is administered and stimulates follicle maturation to preovulatory size, with little or no exposure of the follicles to additional LH. When the follicles have matured to preovulatory size, ovulation is assisted by the administration of hCG. The couple is then advised to engage in sexual intercourse daily, beginning on the day before hCG administration and until ovulation has occurred.

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