(+/-)-블비스타틴

한글명:(+/-)-블비스타틴

카스 번호674289-55-5

상품명:(+/-)-BLEBBISTATIN

CBNumberCB0787697

분자식C18H16N2O2

포뮬러 무게292.33

MOL 파일674289-55-5.mol

동의어(한글)

(+/-)-블비스타틴

화학적 성질

녹는점	210-212°C
끓는 점	507.3±60.0 °C(Predicted)
밀도	1.31±0.1 g/cm3(Predicted)
저장 조건	−20°C
용해도	클로로포름(약간 용해됨), 디클로로메탄, DMSO, 에틸아세테이트, 메탄올에 용해됨
물리적 상태	밝은 노란색 고체.
산도 계수 (pKa)	11.15±0.20(Predicted)
색상	노란색
CAS 데이터베이스	674289-55-5

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

20/21/22-36/37/38

안전지침서

26-36/37

NFPA 704:

	0
3		0

그림문자(GHS)

(+/-)-블비스타틴 화학적 특성, 용도, 생산

개요
(±)-Blebbistatin is a racemic mixture of (–)-blebbistatin and (+)-blebbistatin , the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC₅₀ = 8 μM). Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
화학적 성질
Bright Yellow Solid
용도
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
정의
ChEBI: A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase ac ivity of non-muscle myosin II.
생물학적 활성
Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

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