(S)-(+)-이부프로펜

한글명:(S)-(+)-이부프로펜

카스 번호51146-56-6

상품명:(S)-(+)-Ibuprofen

CBNumberCB0699655

분자식C13H18O2

포뮬러 무게206.28

MOL 파일51146-56-6.mol

동의어(한글)

(S)-(+)-이부프로펜

화학적 성질

녹는점	49-53 °C(lit.)
알파	57 º (c=2, EtOH)
끓는 점	285.14°C (rough estimate)
밀도	1.0364 (rough estimate)
굴절률	59 ° (C=2, EtOH)
인화점	>230 °F
저장 조건	Sealed in dry,Room Temperature
용해도	45%(w/v) 수성 2-히드록시프로필-β-시클로덱스트린: 1.5mg/mL
산도 계수 (pKa)	4.41±0.10(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	하얀색
optical activity	[α]20/D +59°, c = 2 in ethanol
수용성	불용성
BRN	3590022
안정성	안정적인. 강한 산화제와 호환되지 않습니다.
InChIKey	HEFNNWSXXWATRW-JTQLQIEISA-N
CAS 데이터베이스	51146-56-6(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

63-22

안전지침서

45-36/37

WGK 독일

HS 번호

29163990

NFPA 704:

	0
2		0

그림문자(GHS)

(S)-(+)-이부프로펜 화학적 특성, 용도, 생산

개요
Dexibuprofen, the S-(+)-isomer of the widely used NSAID agent ibuprofen, was launched in Austria for the treatment of rheumatoid arthritis. While the racemic compound is commonly used clinically, the antiinflammatory activity is mediated via the S-isomer by inhibition of prostaglandin synthesis. It has also been demonstrated that the R-isomer is converted to the Santipode in vivo via a CoA thioester intermediate. Since CoA plays a pivotal role in intermediary metabolism and maintenance of the [acyl-CoA], generation of R-ibuprofen-CoA competitively inhibits many CoA-dependent reactions, which consequently produces perturbations of hepatocyte Intermediary metabolism and mitocondrial function. Pure S-ibuprofen usage, therefore, is preferred allowing a reduction in dosage level and an improved side effect profile.
화학적 성질
Colourless, Crystalline Solid
용도
A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer
일반 설명
(S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form.
생물학적 활성
Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC 50 values are 12 and 80 μ M respectively). Active isomer of ibuprofen.
Purification Methods
Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

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