2-Bromo-4-chloro-1-iodobenzene

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P304+P340：흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P405：밀봉하여 저장하시오.

2-Bromo-4-chloro-1-iodobenzene 화학적 특성, 용도, 생산

• Synthesis

  2-Bromo-4-chloroaniline (10 g, 48 mmol) was suspended in hydrochloric acid water (50 mL of concentrated hydrochloric acid and 35 mL of water), and the suspension was cooled on a dry ice/methanol bath at -15°C. A sodium nitrite aqueous solution (3.6 g, 52 mmol, 1. 1 eq. /20 mL) was gradually added dropwise to it over 20 minutes, and the mixture was stirred from -15°C to 0°C for 30 minutes, thereby preparing a diazonium salt. The reaction solution was gradually added dropwise to a potassium iodide aqueous solution (73 g, 0.44 mol, 9 eq. /220 mL) at room temperature for 10 minutes. The reaction mixture was stirred at room temperature for 6 hours and then allowed to stand overnight. Dichloromethane (200 mL) was added to the reaction mixture, and subsequently, sodium hydrogensulfite (2 g) was added, deactivating the generated iodine. An organic layer was aliquoted, washed with a 10 % sodium hydrogensulfite aqueous solution (100 mL) and saturated salt water (30 mL) and dried over anhydrous magnesium sulfate. The solvent was then distilled off to obtain a red liquid. This was purified using column chromatography (silica gel/hexane) to obtain a white needle crystal 2-Bromo-4-chloro-1-iodobenzene (12.4 g, 81 %).

2-Bromo-4-chloro-1-iodobenzene 준비 용품 및 원자재

2-Bromo-4-chloro-1-iodobenzene 공급 업체

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