2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE

2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE 화학적 특성, 용도, 생산

• 개요

  Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC₅₀s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (K_is = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC₅₀ value of 7.7 μM independent of MAO-A activity.

• 용도

  Antidepressive;Monoamine oxidase inhibitor

• 생물학적 활성

  A highly selective reversible inhibitor of monoamine oxidase type A.

2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE 공급 업체

Global(36)Suppliers