Anti-Phosphotyrosine antibody, Mouse monoclonal

Anti-Phosphotyrosine antibody, Mouse monoclonal 화학적 특성, 용도, 생산

• 용도

  Anti-Phosphotyrosine antibody, Mouse monoclonal has been used in:
  
  • enzyme linked immunosorbent assay (ELISA)
  • western blot
  • immunohistochemistry
  
  

• 일반 설명

  As determined by ELISA and competitive ELISA, the antibody reacts specifically with phosphorylated tyrosine, both as free amino acid or conjugated to carriers such as BSA or KLH. No cross-reactivity is observed with non-phosphorylated tyrosine, phosphothreonine, phosphoserine, AMP or ATP.

• Biochem/physiol Actions

  Protein phosphorylation is a basic signaling mechanism that modifies protein function in eukaryotic cells. Serine, threonine, and tyrosine are the major phosphorylated amino acids in proteins. Tyrosine phosphorylation is a rare post-translational event in normal tissues, accounting for only 0.03% of phosphorylated amino acids. However, this phosphorylation increases several folds by various activation signals and the process is mediated by protein tyrosine kinases. Protein-tyrosine kinases (PTKs) are enzymes that catalyze the transfer of γ-phosphate of ATP to tyrosine residues of protein substrates. The PTKs are responsible for many biological processes like cell cycle, proliferation, oncogenesis, and development.

Anti-Phosphotyrosine antibody, Mouse monoclonal 공급 업체

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