Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
Biochem/physiol Actions
Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.
