디석신이미딜글루타레이트

한글명:디석신이미딜글루타레이트

카스 번호79642-50-5

상품명:Disuccinimidyl glutarate

CBNumberCB0373852

분자식C13H14N2O8

포뮬러 무게326.26

MOL 파일79642-50-5.mol

동의어(한글)

디석신이미딜글루타레이트

화학적 성질

녹는점	168-172 °C
끓는 점	485.1±55.0 °C(Predicted)
밀도	1.53±0.1 g/cm3(Predicted)
저장 조건	-20°C
용해도	디메틸설폭사이드와 디메틸포름아미드에 용해됩니다.
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
수용성	물에 부분적으로 용해됩니다.
감도	Moisture Sensitive
BRN	8575145
안정성	흡습성, 수분에 민감하고 산성 수용액에서 불안정함
InChI	InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChIKey	LNQHREYHFRFJAU-UHFFFAOYSA-N
SMILES	C(ON1C(=O)CCC1=O)(=O)CCCC(ON1C(=O)CCC1=O)=O
CAS 데이터베이스	79642-50-5

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36

WGK 독일

F 고인화성물질

10-21

HS 번호

29280000

NFPA 704:

	1
2		0

그림문자(GHS)

디석신이미딜글루타레이트 화학적 특성, 용도, 생산

개요
Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.
화학적 성질
DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step crosslinking strategy greatly improves the ChIP assay. Disuccinimidyl crosslinkers include disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS), and bis-N-succinimidyl-(pentaethylene glycol) ester (BS(PEG)5)[1]. DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSS (crosslinker arm length = 11.4Å), DSG (crosslinker arm length = 7.5Å), and disuccinimidyl tartrate (DST, crosslinker arm length = 5.8Å) are homobifunctional crosslinking reagents that react specifically with primary amines[2]. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then added to an aqueous crosslinking reaction. The directly water-soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.
Characteristics
Features of disuccinimidyl glutarate:
Reactive groups: NHS ester (both ends)
Reactive towards: amino groups (primary amines)
Non-cleavable
Water-insoluble (dissolve first in DMF or DMSO)
Membrane-permeable, allowing for intracellular crosslinking
Can increase crosslinking efficiency compared to DSS in some applications
용도
Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.
일반 설명
DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step cross-linking strategy greatly improves the ChIP assay.
DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction. The directly water soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

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