5-HYDROXYINDOLE-3-ACETIC ACID

한글명:5-HYDROXYINDOLE-3-ACETIC ACID

카스 번호54-16-0

상품명:5-HYDROXYINDOLE-3-ACETIC ACID

CBNumberCB0362913

분자식C10H9NO3

포뮬러 무게191.18

MOL 파일54-16-0.mol

화학적 성질

녹는점	161-164 °C (dec.) (lit.)
끓는 점	326.92°C (rough estimate)
밀도	1.2722 (rough estimate)
굴절률	1.5310 (estimate)
저장 조건	-20°C
용해도	에탄올(50mg/ml)에 용해됩니다.
산도 계수 (pKa)	4.54±0.30(Predicted)
물리적 상태	수정 같은
색상	황백색에서 보라색까지
감도	Light Sensitive
BRN	168797
안정성	공기 민감성, 빛 민감성
InChIKey	DUUGKQCEGZLZNO-UHFFFAOYSA-N
CAS 데이터베이스	54-16-0

위험 및 안전 성명

안전지침서

22-24/25

WGK 독일

RTECS 번호

NL3650000

F 고인화성물질

8-10-23

HS 번호

29339980

NFPA 704:

	1
1		0

그림문자(GHS)

5-HYDROXYINDOLE-3-ACETIC ACID 화학적 특성, 용도, 생산

개요
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
화학적 성질
beige crystalline powder
용도
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
정의
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
일반 설명
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.

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