(±)16-HETE

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

(±)16-HETE 화학적 특성, 용도, 생산

• 개요

  Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.

• 정의

  ChEBI: A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 16.

(±)16-HETE 공급 업체

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