Di-tert-butyl Chloromethyl Phosphate

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• 그림문자(GHS)

  

• 신호 어

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Di-tert-butyl Chloromethyl Phosphate 화학적 특성, 용도, 생산

• 개요

  Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].

• 용도

  Used as an intermediate for laboratory research.

• Synthesis

  Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs,  is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .

Di-tert-butyl Chloromethyl Phosphate 준비 용품 및 원자재

Di-tert-butyl Chloromethyl Phosphate 공급 업체

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