(20S)-3β,20-비스(디메틸아미노)프레그나-5-엔

(20S)-3β,20-비스(디메틸아미노)프레그나-5-엔 화학적 특성, 용도, 생산

• 개요

  A pregnene alkaloid found in the bark of Holarrhena antidysenterica Wall. and also present in the leaves of Sarcococca pruni!ormis Lindl., the base forms colour_x0002_less crystals from Me2CO and has [α]²⁰_D - 37° (c 1.90, CHCl3), - 17° (c 1.OS, MeOH). It contains three methyl groups and two dimethylamino groups in the molecule. The alkaloid is characterized as the crystalline perchlorate, m.p. 277- 9°C (dec.) or the picrate, m.p. 228-230°C. The structure has been established as 3 ,20 -bis (dimethylamino)pregn-S-ene. It is identical with saracodinine.

• 참고 문헌

  Tschesche, Wiensz., Chem. Ber., 91, lS04 (19S8)
  Tschesche, Otto., ibid, 95, 1144 (1962)
  Chatterjee et aI., Tetrahedron Lett., 67 (1965)
  Structure:
  Labler, Sorm., Collect. Czech. Chem. Commun., 28,2345 (1963)