GLP-1

한글명:GLP-1

카스 번호87805-34-3

상품명:GLP-1

CBNumberCB0193173

분자식C186H275N51O59

포뮬러 무게4169.48

MOL 파일Mol file

화학적 성질

저장 조건	−20°C
물리적 상태	고체
물리적 상태	단단한 모양
수용성	Soluble to 5 mg/ml in water
InChIKey	UKVFVQPAANCXIL-FJVFSOETSA-N
CAS 데이터베이스	87805-34-3

위험 및 안전 성명

WGK 독일	3
HS 번호	3504009000

그림문자(GHS)

GLP-1 화학적 특성, 용도, 생산

역사
GLP-1 was first identified in the early 1980s, following the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the N-terminal extended forms of GLP-1(1–37 and 1–36 amide). However, these forms were devoid of biological activity. In the late 1980s, bioactive GLP-1 peptides were purified from gut extracts and were identified to be GLP1(7–37) and GLP-1(7–36)-amide. In the current literature, the unqualified designation of GLP-1 corresponds to the truncated peptides.
용도
Glucagon-Like Peptide I (GLP1) has been used as an antigen in excess amounts for the incubation of primary antibodies, post-immunocytochemistry with positive results of paraffin-embedded pancreatic tissues of Rana temporaria.
일반 설명
Glucagon-Like Peptide I (GLP1) is an incretin hormone, which functions as ligand for GLP1 receptors (GLP1R). These receptors are expressed in renal and cardiovascular system, such as smooth muscle and endothelial cells.
Biochem/physiol Actions
Glucagon-Like Peptide I (GLP1) controls the metabolism of glucose, by inducing the secretion of insulin and suppressing that of glucagon. Studies in Indonesian population show that reduced levels of this protein are linked with increased susceptibility to type 2 diabetes mellitus. Plasma levels of this hormone also show significant association with systolic and diastolic blood pressure levels.
부작용
Common side effects of GLP-1 include: loss of appetite, nausea, vomiting, diarrhoea. Other side effects may include: dizziness, mild tachycardia or increased heart rate, infection, headache, and indigestion. Temporary mild itching and redness of the skin at the injection site may also occur. Serious and rare side effects include: pancreatitis, medullary thyroid cancer, acute (sudden) kidney injury, worsening of diabetes-related retinopathy, and severe allergic reactions. And GLP-1 agonists are recommended during pregnancy because they can cause abnormal foetal development. Seek medical attention if any serious adverse reactions occur.

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