Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody may be used for immunoblotting at a working concentration of 2 μg/ml. For immunohistochemistry a working concentration of 5-15 μg/ml is recommended.
일반 설명
Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. Signaling of NGF through NGFR is also implicated in inflammation and allergic reactions. Expression of NGFR has been associated with favourable prognosis and survival in breast and pancreatic cancers Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes mouse NGF R.
Biochem/physiol Actions
TNFRSF1B (tumor necrosis factor receptor superfamily, member 1B) facilitates TNF-induced programmed necrosis. The activated TNFR-2 recruits RIP (receptor-interacting protein). It cannot participate directly in the cell death signaling. But it enhances the cell death signaling for TNF-1 via TRAF2 (TNFR-associated factor-2) degradation. It facilitates TNF-induced programmed necrosis. It cannot participate directly in the cell death signaling. But it can enhance the cell death signaling for TNF-1 via TRAF2 (TNFR-associated factor-2) degradation.
