3-Butylidenephthalide

한글명:3-Butylidenephthalide

카스 번호551-08-6

상품명:3-Butylidenephthalide

CBNumberCB0173298

분자식C12H12O2

포뮬러 무게188.22

MOL 파일551-08-6.mol

화학적 성질

녹는점	82.5°C
끓는 점	139-142 °C/5 mmHg (lit.)
밀도	1.103 g/mL at 25 °C (lit.)
FEMA	3333 \| 3-BUTYLIDENEPHTHALIDE
굴절률	n20/D 1.577(lit.)
인화점	>230 °F
저장 조건	Refrigerator
용해도	클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨)
물리적 상태	기름
색상	무색~황색
냄새	디프로필렌 글리콜 중 10.00%. 허브 셀러리
?? ??	약초
JECFA Number	1170
BRN	5145
InChIKey	WMBOCUXXNSOQHM-FLIBITNWSA-N
LogP	3.72
CAS 데이터베이스	551-08-6(CAS DataBase Reference)
EPA	1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

WGK 독일

RTECS 번호

TI3692500

TSCA

Yes

NFPA 704:

	1
2		0

그림문자(GHS)

3-Butylidenephthalide 화학적 특성, 용도, 생산

화학적 성질
3-Butylidenephthalide has a pervasive warm spicy aroma.
출처
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale) seeds, roots and leaves.
용도
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
정의
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
일반 설명
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.
Cytotoxicity
The anti-proliferative effects of 3-Butylidenephthalide (n-Butylidenephthalide; BP) on cells from GBM, neuroblastoma, lung cancer, melanoma, teratoma, leukemia, breast cancer and hepatocellular carcinoma, as well as from normal fibroblast and vascular endothelial cells, were determined. The IC50 values of BP after a 48 h incubation with tumor cell lines (IC50: 15–67 μg/mL) were significantly lower than the values for normal fibroblast cells (IC50: >?100 μg/mL, p < 0.0001) or carmustine (BCNU)-treated tumor cells (IC50: 40 ～ 100 μg/mL, p < 0.001; Table 1). In the two normal cell types, vascular endothelial cells (IC50 = 25.0 ± 2.0 μg/mL) were more sensitive to BP than fibroblast cells (IC50 > 100 μg/mL) (p < 0.0001). These experiments showed that BP could induce high cytotoxicity against brain and other tumour cells but only low or no cytotoxicity against normal fibroblast cells.
Safety Profile
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

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