Pyronaridine

Pyronaridine 화학적 특성, 용도, 생산

• 화학적 성질

  solid

• Antimicrobial activity

  Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.

• 원료

  Decreasing in-vitro sensitivity has been observed in China.

• Pharmaceutical Applications

  An aza-aminoacridine formulated for oral use. A Mannichbase derivative of mepacrine.

• Pharmacokinetics

  Peak plasma concentrations are reached after 3–14 h depending upon the formulation; there is also considerable interindividual variation. Elimination half-lives of 63–190 h have been reported, again dependent upon the formulation.

• Clinical Use

  Treatment of uncomplicated P. falciparum and P. vivax malaria
  A fixed-dose combination with artesunate (Pyramax) is being developed for uncomplicated P. falciparum and P. vivax malaria.

• 부작용

  It is well tolerated and no outstanding toxic effects have been reported.

Pyronaridine 공급 업체

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