チリジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P330：口をすすぐこと。

  P501：内容物/容器を．．．に廃棄すること。

チリジン 化学特性,用途語,生産方法

• 効能

  鎮痛薬, オピオイド受容体作動薬

• Originator

  Valoron,Goedecke,W. Germany,1970

• Manufacturing Process

  In a first step, dimethylamine is reacted with crotonaldehyde to give 1- (dimethylamino)-1,3-butadiene.
  A solution of 194 grams (2 mols) of fresh-distilled 1-(dimethylamino)-1,3- butadiene is combined at room temperature in a 1 liter round-bottom flask with 352 grams (2 mols) atropic acid ethyl ester. After being stirred for about 10 minutes, the reaction mixture gradually becomes exothermic. By cooling with ice water, the contents of the flask are kept at a temperature of 40° to 60°C. After the reaction has ceased, the mixture is kept overnight (about 8 to 24 hours) at room temperature. The next day the viscous product is dissolved in 10 liters of ether and precipitated with ethereal hydrogen chloride forming the corresponding hydrochloride. By fractional crystallization from ethyl acetate/methyl ethyl ketone (10:1), an almost complete separation of the isomeric cis/trans isomers (I) and (II) is achieved. The separation can be carried out very easily due to the low solubility of the 1 1/2-hydrate of (I). Therefore, during the crystallization a sufficient quantity of water for the formation of the 1 1/2-hydrate of (I) is added to the mixture of solvents, whereby (I) readily precipitates.
  Isomer (I): 4-phenyl-3-cis-dimethylamino-4-cis-carbethoxy-?1- cyclohexenehydrochloride, [ethyl-cis-3-(dimethylamino)-4-phenyl-1- cyclohexene-4-carboxylate hydrochloride] , MP 84°C (the free base boils at 97.5° to 98°C at 0.01 mm pressure), 64.4% yield.
  Isomer (II): 4-phenyl-3-trans-dimethylamino-4-trans-carbethoxy-?1- cyclohexenehydrochloride, [ethyl-trans-3-(dimethylamino)-4-phenyl-1- cyclohexene-4-carboxylate hydrochloride], MP 159°C (the free base boils at 95.5° to 96°C at 0.01 mm pressure), 22.2% yield.

• Therapeutic Function

  Analgesic

チリジン 上流と下流の製品情報

20380-58-9, チリジン キーワード