1,4,9,10-テトラヒドロ-9,10-[1,2]ベンゼノアントラセン-1,4-ジオン

1,4,9,10-テトラヒドロ-9,10-[1,2]ベンゼノアントラセン-1,4-ジオン 価格

1,4,9,10-テトラヒドロ-9,10-[1,2]ベンゼノアントラセン-1,4-ジオン 化学特性,用途語,生産方法

• 説明

  NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (K_d = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.

• 使用

  INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs.

• 一般的な説明

  A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (K_d = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.

• 生物活性

  Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

1,4,9,10-テトラヒドロ-9,10-[1,2]ベンゼノアントラセン-1,4-ジオン 生産企業

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1,4,9,10-テトラヒドロ-9,10-[1,2]ベンゼノアントラセン-1,4-ジオン スペクトルデータ(¹HNMR)

3519-82-2, 1,4,9,10-テトラヒドロ-9,10-[1,2]ベンゼノアントラセン-1,4-ジオン キーワード