B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H227：引火性液体

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

  P370+P378：火災の場合：消火に．．．を使用すること。

  P403+P235：換気の良い場所で保管すること。涼しいところに 置くこと。

  P501：内容物/容器を．．．に廃棄すること。

B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid 化学特性,用途語,生産方法

• 使用

  B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

• 合成

  
  12.6g of intermediate (A) and 500 mL of tetrahydrofuran (dehydrated) were put in a flask, and the resultant was cooled to -78??C. 28 mL of n-BuLi (1.60M in hexane) was added, and stirring was conducted for 2 hours while elevating the temperature to 0??C. Then, the solution was again cooled to -78??C, and 11.6g of B(OMe) 3 was added. After stirring at 10 minutes at -78??C, stirring was further conducted for 5 hours while gradually elevating the temperature to room temperature. After completion of the reaction, 1 N HCl aq. (100 mL) was added, and the reaction solution was stirred at room temperature for 1 hour. Then, the solution was transferred to a separating funnel, and extracted with ethyl acetate. This solution was dried with MgSO 4, concentrated and washed with hexane, whereby 7.2g (yield: 65%) of white solids of intermediate (B) were obtained.

B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid 生産企業

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