3-メトキシ-3,3-ジフェニル-N-(2-プロペニル)-1-プロパンアミン

3-メトキシ-3,3-ジフェニル-N-(2-プロペニル)-1-プロパンアミン 化学特性,用途語,生産方法

• Originator

  Alimadol ,ZYF Pharm Chemical

• Manufacturing Process

  12 g 3,3-diphenyl-3-methoxypropylamine, 13.5 g trifluoroacetic acid anhydride, 6.0 g pyridine and 100 ml benzene was heated by stirring for 1 hour at 40°C. Then in was cooled to 0°C and poured in water. The organic layer was separated, washed with diluted HCl and water, and evaporated to dryness. The residue N-(3,3-diphenyl-3-methoxypropyl)trifluoroacetamide melted at 108°-110°C. Yield: 98%.
  8 g above amide was in 80 ml hexamethyl phosphoric acid amide dissolved mixed with 1.7 g sodium hydride and stirred for 3 hours. Then 5.7 g allyl bromide was added dropwise and the mixture was stirred for 30 minutes. It was diluted with water and extracted with benzene. Benzene layer was separated, evaporated to dryness. The residue was mixed with 100 ml of 75% ethanol and 1 g sodium hydroxide and heated for 1 hour. Ethanol was distilled off and reaction product was extracted with ether. Yield of N-(3-methoxy-3,3- diphenylpropyl)allylamin (or 1,1-diphenyl-1-methoxy-3-allylaminopropane) was 6.5 g (97%). MP: 40°-50°C. Hydrochloride melted at 137°-138°C.
  

• Therapeutic Function

  Analgesic

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