(S)-(+)-2-アミノ-1-プロパノール

化学名:(S)-(+)-2-アミノ-1-プロパノール

CAS番号.2749-11-3

英語名:L-Alaninol

CBNumberCB8693194

MFC3H9NO

MW75.11

别名

(S)-(+)-2-アミノ-1-プロパノール

L-アラニノール

(S)‐(+)‐2‐アミノ‐1‐プロパノール

(S)-(+)-2-アミノ-1-プロパノール物理性質

融点	-2°C
比旋光度	21.8 º (c=2,ethanol)
沸点	72-73 °C11 mm Hg(lit.)
比重(密度)	0.965 g/mL at 25 °C(lit.)
屈折率	n20/D 1.450
闪点	145 °F
貯蔵温度	Keep in dark place,Inert atmosphere,2-8°C
水溶解度	Completely miscible in water
溶解性	Chloroform, Methanol (Slightly)
外見	油性液体
酸解離定数(Pka)	12.88±0.10(Predicted)
比重	0.96
色	無色透明～黄色
旋光度（Optical Rotation）	[α]20/D +18°, neat
Sensitive	Hygroscopic
BRN	1718865
InChI	1S/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3/t3-/m0/s1
InChIKey	BKMMTJMQCTUHRP-VKHMYHEASA-N
SMILES	C[C@H](N)CO
CAS データベース	2749-11-3(CAS DataBase Reference)
NISTの化学物質情報	1-Propanol, 2-amino-, (S)-(2749-11-3)

安全性情報

主な危険性	C,Xi
Rフレーズ	34-36/37/38
Sフレーズ	26-36/37/39-45-36
RIDADR	UN 2735 8/PG 2
WGK Germany	3
F	10-23
国連危険物分類	8
容器等級	III
HSコード	29221990
ストレージクラス	8A - Combustible corrosive hazardous materials
Hazard Classifications	Skin Corr. 1B
消防法	危-4-3-III
化審法	(9)-122, (2)-323

危険有害性情報のコード(GHS)

外観
無色～うすい黄色、液体
用途
有機合成原料。
化学的特性
Colorless liquid
使用
S-(+)-2-Amino-1-propanol is an aliphatic amino alcohol shown to induce an antiproliferative effect in B16 melanoma cells. S-(+)-2-Amino-1-propanol is used in the preparation of oxazolines which are of ten used as ligands in homogeneous catalysis.
定義
ChEBI: (S)-2-aminopropan-1-ol is a 2-aminopropan-1-ol that has S-configuration. It is a conjugate base of a (S)-2-aminopropan-1-ol(1+). It is an enantiomer of a (R)-2-aminopropan-1-ol.
合成
Simply produce L-alaninol in high yield and good reproducibility by directly reducing an inorganic acid salt of an L-alanine ester with NaBH4. 3.0 mol of NaBH 4 was added and dissolved in 560 ml of cold water, and L-alanine ethyl ester hydrochloride 1. A solution of 0 mol dissolved in 560 ml of ethanol was added. The mixture was added dropwise at 20 ° C. over 5 hours and further aged at 20 to 28 ° C. to complete the reaction. After the reaction, excess NaBH 4 was decomposed with acetone, 1000 ml of ethyl acetate was introduced, and the precipitated inorganic substance was separated by filtration. The lower aqueous layer portion of the filtrate was extracted with 600 ml of ethyl acetate; the ethyl acetate layer was distilled under reduced pressure to remove the solvent and then vacuum distilled to yield L-alaninol.
純化方法
Purify it as for S-2-amino-3-methylbutan-1-ol below. [Beilstein 4 IV 1615.]

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