α-シアノ-2-アミノ-3-(エトキシカルボニル)-6-クロロ-4H-1-ベンゾピラン-4-酢酸エチル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

α-シアノ-2-アミノ-3-(エトキシカルボニル)-6-クロロ-4H-1-ベンゾピラン-4-酢酸エチル 価格

α-シアノ-2-アミノ-3-(エトキシカルボニル)-6-クロロ-4H-1-ベンゾピラン-4-酢酸エチル 化学特性,用途語,生産方法

• 説明

  SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. For example, both Thr³⁰⁸ and Ser⁴⁷³ on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 μg/ml). SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling. SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.

• 使用

  SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid.

• 一般的な説明

  A cell-permeable and blood-brain barrier permeant bromo-to-chloro substituted HA14-1 (Cat. No. 371971) analog that renders Akt in a conformation susceptible to phosphorylation by upstream kinases via specific interaction with Akt pleckstrin homology (PH) domain PtdIns(3,4,5)P3- (PIP3) binding pocket. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473) in a time- and dose-dependent manner (2 to 4 μg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC₅₀ = 4 μg/ml) in vitro and in a murine MCAO (middle cerebral artery occlusion) model (40 mg/kg, i.p.) in vivo.

α-シアノ-2-アミノ-3-(エトキシカルボニル)-6-クロロ-4H-1-ベンゾピラン-4-酢酸エチル 生産企業

Global(112)Suppliers

α-シアノ-2-アミノ-3-(エトキシカルボニル)-6-クロロ-4H-1-ベンゾピラン-4-酢酸エチル スペクトルデータ(¹HNMR)

305834-79-1, α-シアノ-2-アミノ-3-(エトキシカルボニル)-6-クロロ-4H-1-ベンゾピラン-4-酢酸エチル キーワード