N-(5-クロロ-6-メチルベンゾチアゾール-2-イル)-2-フェニルアセトアミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H320：眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

N-(5-クロロ-6-メチルベンゾチアゾール-2-イル)-2-フェニルアセトアミド 価格

N-(5-クロロ-6-メチルベンゾチアゾール-2-イル)-2-フェニルアセトアミド 化学特性,用途語,生産方法

• 使用

  LH 846 modulates circadian rhythms in human cells by inhibiting CK1δ-dependent phosphorylation and subsequent degradation of PER1.

• 一般的な説明

  A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC₅₀ = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC₅₀ =1.3 and 2.5 μM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 μM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.

• Biochem/physiol Actions

  LH846 is a potent and selective inhibitor of the known clock regulatory kinase Casein Kinase CK1δ, with an IC50 of 290 nm, compared to an IC50 of 2.5 μm for CKIα , 1.3 μm for CKIε, and minimal effect on CK2 and 50 other kinases tested. Circadian rhythym has been studied for a long time for things such as jet lag rhythym related disorders, but more recently it has beencome apparent that clock dysfunction can contribute to a variety of pathologies including circadian sleep disorders, cardiovascular disease, cancer, and metabolic disease, so studies of clock regulating enzymes have increased. LH846 increased circadian period by 10 hours in human U2OS cells.

N-(5-クロロ-6-メチルベンゾチアゾール-2-イル)-2-フェニルアセトアミド 生産企業

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N-(5-クロロ-6-メチルベンゾチアゾール-2-イル)-2-フェニルアセトアミド スペクトルデータ(¹HNMR)

639052-78-1, N-(5-クロロ-6-メチルベンゾチアゾール-2-イル)-2-フェニルアセトアミド キーワード