2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H312：皮膚に接触すると有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate 化学特性,用途語,生産方法

• 化学的特性

  white to yellow Solid.

• 使用

  It is employed as a intermediate for pharmaceutical.

• 製造方法

  Synthesis of 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate: Take a 500mL single-necked bottle, add 6-toluenesulfonyl-2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester (7g, 20mmol), dissolve in methanol (200mL), add magnesium chips (3.84 g) g, 0.16 mol, 8 equiv) and stirred at room temperature. The reaction solution gradually turned into a white viscous state with the dissolution of the magnesium scraps, and TLC showed that the reaction of the raw materials was completed. The solvent was removed by rotary evaporation, ether (150 mL) was added, stirred at room temperature for 1 h, filtered through celite, the filtrate was dried over anhydrous sodium sulfate, and an ethanol solution (3 mL) of anhydrous oxalic acid (0.89 g, 9.9 mmol, 0.5 equiv) was added dropwise, A white precipitate appeared immediately, which was filtered under reduced pressure to give 3.2 g of a colorless solid, 82%.

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate 生産企業

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2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate スペクトルデータ(¹HNMR、FT-IR)

1041026-71-4, 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate キーワード