2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル 価格

2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル 化学特性,用途語,生産方法

• 化学的特性

  White powder

• 合成

  To a flame-dried RB flask with tert-butyl 4-methylenepiperidine-1- carboxylate (2.96 g, 15 mmol, 1.0 equiv) and Zn/Cu couple (6.54 g, 172.5 mmol, 11.5 equiv) under vacuum, t-BuOMe (60 mL) was charged and refilled the flask with N2 balloon. To the mixture thus obtained stirred at 15 °C, a solution of 2,2,2- trichloroacetyl chloride in DME (20 mL) was added dropwise. The mixture was stirred at room temperature overnight after addition. To the reaction mixture stirred in an external ice- bath, a saturated solution of NH4CI (60 mL) was added slowly and carefully (especially the first few drops). After addition, the mixture was stirred at room temperature for 4 h and filtered to remove the solid. The phases were separated. The aqueous phase was extracted with EtOAc. The combined organic phase was washed with brine, dried over anhydrous Na2S04, and concentrated to give the residue, which was purified by CombiFlash (40 g silica gel column, EtOAc/Hexane: 0-40percent) to afford 619 mg (15%) of tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate.

2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル 上流と下流の製品情報

2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル 生産企業

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2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル スペクトルデータ(¹HNMR)

203661-69-2, 2-オキソ-7-アザスピロ[3.5]ノナン-7-カルボン酸 TERT-ブチル キーワード